CHIMUSA, Emile Rugamika
Bx, BioStatistician, CPGR/H3Bionet, Centre for Proteomic and Genomic Research
PhD, University of Cape Town, 2013
BioProfil: Emile received his Bsc in Applied Mathematics at University of Kinshasa. Later on he joined the independent electoral commission (IEC) for United Nations mission in Democratic Republic of Congo (DRC), as software developer and database administrator. He joined the African Institute for Mathematical Sciences in 2007 and obtained his post-graduate diploma in Mathematical sciences at the University of Western Cape, South Africa. He completed his PhD from University of Cape Town, South Africa in Bioinformatics and Computational Biology. During his last year of PhD (2012) Emile later joined African institute for Mathematical Sciences as IT and teaching assistant.
Emile is a mathematical population geneticist whose main focus of research is ”Medical Population Genetics and Computational Statistics methods for mapping complex diseases”. Emile’s interest focuses are in computational and statistical methods for understanding both the genetics and environment architecture of genetic diseases. He is interesting in investigating methodologies of improvement the analysis of large scale genomic studies such as genome-wide association studies or fine-mapping studies and analysing genome wide patterns of variation within and between species to address fundamental questions in biology, anthropology, and medicine. Emile is currently investigating on statistical and computational approach for estimating the heritability of the traits (diseases) using the DNA sequence data of both parents and children particularly new born-babies (family-based) (1) to understand the fraction of phenotypic (traits or diseases) explained by DNA sequence (2) to predict genetic architecture of complex traits (such TB and HIV), and variation in drug/treatment responses at early stage in children (3) to optimal prescription and usage of medicines to effectively manage and treat infectious and non-communicable diseases in Sub Saharan African populations. The long term of his research is to conduct a cohort study in sequencing South African's parents within children or baby-born with tuberculosis and HIV and apply the developed approach in both tuberculosis and HIV public sequence data of children or baby-born.
Emile's project will develop important skills, further job opportunities and tools required for medical population genetic research in Sub-Sahara and South Africa. A wide variety of fields stand to benefit from this research. These fields include the pharmaceutical, biotechnology, computational biology, biostatistics and diagnostic areas. Significant findings milestones achieved are to be disseminated in the form of publications in high-impact international journals and presented at both local and international conferences.
Emile has trained, supervised and co-supervised several AIMS students and masters students (all former AIMS students). He is one of the first recipients of the AASRG. This grant a great start for his early scientific career. The AASRG will help Emile in supporting other AIMS students through supervision
Emile's advise to youths is: (1) Never fail having a dream. Once you have a dream, give it a go ahead and tries. (2) Understanding your mistakes and failures is a starting point to overcome and getting into the track of your success.